Resistance to coronavirus infection in amino peptidase N-deficient pigs
Identifieur interne : 000699 ( Main/Exploration ); précédent : 000698; suivant : 000700Resistance to coronavirus infection in amino peptidase N-deficient pigs
Auteurs : Kristin M. Whitworth [États-Unis] ; Raymond R. R. Rowland [États-Unis] ; Vlad Petrovan [États-Unis] ; Maureen Sheahan [États-Unis] ; Ada G. Cino-Ozuna [États-Unis] ; Ying Fang [États-Unis] ; Richard Hesse [États-Unis] ; Alan Mileham [États-Unis] ; Melissa S. Samuel [États-Unis] ; Kevin D. Wells [États-Unis] ; Randall S. Prather [États-Unis]Source :
- Transgenic Research [ 0962-8819 ] ; 2018.
Abstract
The alphacoronaviruses, transmissible gastroenteritis virus (TGEV) and Porcine epidemic diarrhea virus (PEDV) are sources of high morbidity and mortality in neonatal pigs, a consequence of dehydration caused by the infection and necrosis of enterocytes. The biological relevance of amino peptidase N (ANPEP) as a putative receptor for TGEV and PEDV in pigs was evaluated by using CRISPR/Cas9 to edit exon 2 of
The online version of this article (10.1007/s11248-018-0100-3) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s11248-018-0100-3
PubMed: 30315482
PubMed Central: 6353812
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Curation: 000729
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Le document en format XML
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Samuel</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2162 3504</institution-id><institution-id institution-id-type="GRID">grid.134936.a</institution-id><institution>Division of Animal Science,</institution><institution>University of Missouri,</institution></institution-wrap>Randall Prather, 920 East Campus Drive, Columbia, MO 65211 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Randall Prather, 920 East Campus Drive, Columbia</wicri:cityArea></affiliation></author><author><name sortKey="Wells, Kevin D" sort="Wells, Kevin D" uniqKey="Wells K" first="Kevin D." last="Wells">Kevin D. Wells</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2162 3504</institution-id><institution-id institution-id-type="GRID">grid.134936.a</institution-id><institution>Division of Animal Science,</institution><institution>University of Missouri,</institution></institution-wrap>Randall Prather, 920 East Campus Drive, Columbia, MO 65211 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Randall Prather, 920 East Campus Drive, Columbia</wicri:cityArea></affiliation></author><author><name sortKey="Prather, Randall S" sort="Prather, Randall S" uniqKey="Prather R" first="Randall S." last="Prather">Randall S. Prather</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2162 3504</institution-id><institution-id institution-id-type="GRID">grid.134936.a</institution-id><institution>Division of Animal Science,</institution><institution>University of Missouri,</institution></institution-wrap>Randall Prather, 920 East Campus Drive, Columbia, MO 65211 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Randall Prather, 920 East Campus Drive, Columbia</wicri:cityArea></affiliation></author></analytic><series><title level="j">Transgenic Research</title><idno type="ISSN">0962-8819</idno><idno type="eISSN">1573-9368</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The alphacoronaviruses, transmissible gastroenteritis virus (TGEV) and Porcine epidemic diarrhea virus (PEDV) are sources of high morbidity and mortality in neonatal pigs, a consequence of dehydration caused by the infection and necrosis of enterocytes. The biological relevance of amino peptidase N (ANPEP) as a putative receptor for TGEV and PEDV in pigs was evaluated by using CRISPR/Cas9 to edit exon 2 of <italic>ANPEP</italic> resulting in a premature stop codon. Knockout pigs possessing the null ANPEP phenotype and age matched wild type pigs were challenged with either PEDV or TGEV. Fecal swabs were collected daily from each animal beginning 1 day prior to challenge with PEDV until the termination of the study. The presence of virus nucleic acid was determined by PCR. <italic>ANPEP</italic> null pigs did not support infection with TGEV, but retained susceptibility to infection with PEDV. Immunohistochemistry confirmed the presence of PEDV reactivity and absence of TGEV reactivity in the enterocytes lining the ileum in <italic>ANPEP</italic> null pigs. The different receptor requirements for TGEV and PEDV have important implications in the development of new genetic tools for the control of enteric disease in pigs.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1007/s11248-018-0100-3) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abeydeera, Lr" uniqKey="Abeydeera L">LR Abeydeera</name></author><author><name sortKey="Wang, Wh" uniqKey="Wang W">WH Wang</name></author><author><name sortKey="Cantley, Tc" uniqKey="Cantley T">TC Cantley</name></author><author><name sortKey="Prather, Rs" uniqKey="Prather R">RS Prather</name></author><author><name sortKey="Day, Bn" uniqKey="Day B">BN Day</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beaton, Bp" uniqKey="Beaton B">BP Beaton</name></author><author><name sortKey="Wells, 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R">RA Ashmun</name></author><author><name sortKey="Williams, Rk" uniqKey="Williams R">RK Williams</name></author><author><name sortKey="Cardellichio, Cb" uniqKey="Cardellichio C">CB Cardellichio</name></author><author><name sortKey="Shapiro, Lh" uniqKey="Shapiro L">LH Shapiro</name></author><author><name sortKey="Look, At" uniqKey="Look A">AT Look</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshioka, K" uniqKey="Yoshioka K">K Yoshioka</name></author><author><name sortKey="Suzuki, C" uniqKey="Suzuki C">C Suzuki</name></author><author><name sortKey="Tanaka, A" uniqKey="Tanaka A">A Tanaka</name></author><author><name sortKey="Anas, Im" uniqKey="Anas I">IM Anas</name></author><author><name sortKey="Iwamura, S" uniqKey="Iwamura S">S Iwamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kansas</li><li>Missouri (État)</li><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Whitworth, Kristin M" sort="Whitworth, Kristin M" uniqKey="Whitworth K" first="Kristin M." last="Whitworth">Kristin M. Whitworth</name></region><name sortKey="Cino Ozuna, Ada G" sort="Cino Ozuna, Ada G" uniqKey="Cino Ozuna A" first="Ada G." last="Cino-Ozuna">Ada G. Cino-Ozuna</name><name sortKey="Fang, Ying" sort="Fang, Ying" uniqKey="Fang Y" first="Ying" last="Fang">Ying Fang</name><name sortKey="Hesse, Richard" sort="Hesse, Richard" uniqKey="Hesse R" first="Richard" last="Hesse">Richard Hesse</name><name sortKey="Mileham, Alan" sort="Mileham, Alan" uniqKey="Mileham A" first="Alan" last="Mileham">Alan Mileham</name><name sortKey="Petrovan, Vlad" sort="Petrovan, Vlad" uniqKey="Petrovan V" first="Vlad" last="Petrovan">Vlad Petrovan</name><name sortKey="Prather, Randall S" sort="Prather, Randall S" uniqKey="Prather R" first="Randall S." last="Prather">Randall S. Prather</name><name sortKey="Rowland, Raymond R R" sort="Rowland, Raymond R R" uniqKey="Rowland R" first="Raymond R. R." last="Rowland">Raymond R. R. Rowland</name><name sortKey="Samuel, Melissa S" sort="Samuel, Melissa S" uniqKey="Samuel M" first="Melissa S." last="Samuel">Melissa S. Samuel</name><name sortKey="Sheahan, Maureen" sort="Sheahan, Maureen" uniqKey="Sheahan M" first="Maureen" last="Sheahan">Maureen Sheahan</name><name sortKey="Wells, Kevin D" sort="Wells, Kevin D" uniqKey="Wells K" first="Kevin D." last="Wells">Kevin D. Wells</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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